The non-selective NSAID diclofenac was associated with an increased leak rate, but ketorolac was not. Non-selective NSAIDs were associated with an increased risk, but selective NSAIDs were not.
Use of an NSAID post-operatively was associated with an overall increased risk of anastomotic leakage. Seven studies were included in the final review. Meta-analysis was performed to assess for overall risk of anastomotic leak with NSAID use, as well as sub-group analysis to compare selective vs non-selective NSAIDs and drug-specific NSAID safety profiles. MethodsĪ systematic review was performed for studies investigating anastomotic leak rate following NSAID use vs control after colonic or rectal anastomosis. The present study aims to assess whether post-operative NSAID use is associated with an increased anastomotic leak rate after a colonic or rectal anastomosis. Current enhanced recovery guidelines suggest that opioid sparing medications should be used for analgesia whenever possible following colorectal surgery.
0 kommentar(er)
